Endocrine Abstracts

Objective: Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity including hypertension with a prevalence ranging from 40 to 65%. The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of sodium/potassium balance, volume homeostasis as well as blood pressure. There is increasing evidence of interactions between calcium and calcium-regulatory hormones with the RAAS. The aim of this study was to investigate the associ...

Background: DiGeorge syndrome (DGS) is the rare genetic disorder caused by a 22q11.2 chromosome microdeletion. The main clinical features are associated with defective development of the pharyngeal pouch system and usually include congenital heart disease, hypoplasia of thymus resulting in immune deficiency and hypoparathyroidism. Also DGS patient has characteristic long face with narrow palpebral fissures, broad nasal bridge, micrognathia and small mouth, small dysmorphic ear...

Background: Hypertension is one of the widespread cardiovascular pathology in patients with primary hyperparathyroidism (PHPT).The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of blood pressure and its interactions with mineral metabolism are described. Our previous study* of PHPT patients revealed a significant decrease in plasma renin activity (PRA) and serum aldosterone levels in the early postoperative period and also positive correlations ...

BackgroundMost cases of primary hyperparathyroidism (PHPT) is caused by a single benign adenoma, multiple parathyroid neoplasms (MPN) occur less often in 10–15%, parathyroid carcinoma accounts for <3%. MPN can be sporadic or develop due to inherited genetic syndromes (most commonly multiple endocrine neoplasia syndrome type 1 (MEN-1) that usually manifest at a young age. The preoperative examination of patients with MPN is important for achievin...

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT) and extremely rare endocrine malignancy during pregnancy. Different maternal and fetal/neonatal complications of PHPT occur in 67 and 80% of untreated cases respectively, probably more due to severe hypercalcemia.The diagnostic and therapeutic approaches are limited in pregnant women and require individual risk-benefit assessment.Aim: We present a case of PC mani...

BackgroundThe nonclassical complications of primary hyperparathyroidism (PHPT) can include metabolic syndrome associated with cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia and other disorders are observed in patients with PHPT regardless of the severity of the disease. The aim of this study is to estimate metabolic parameters in patients with PHPT compared to...

Background: Metabolic syndrome may be the nonclassical feature of primary hyperparathyroidism (PHPT) because an increased incidence of various glucose and lipid disorders is often observed in patients with this disease. Earlier we showed PHPT patients had higher serum triglycerides and higher rate of insulin resistance compared to the control group. Dynamics of metabolic parameters after surgery is ambiguous.The aim: of this study was to compare metaboli...

Objective: Normocalcemic primary hyperparathyroidism (PHPT) is a phenotype of PHPT characterized by normal serum calcium and persistently increased parathyroid hormone (PTH) after exclusion of secondary causes of PTH elevation.The aim: of this study was to investigate the capability of the short test with active metabolites of vitamin D for differential diagnosis between normocalcemic PHPT and secondary hyperparathyroidism (SHPT) for inpatient treatment....

Introduction: An atypical manifestation of disease combined with inconsistent results of examination, long history of multiple past health care services without effect requires to consider factitious disorders.Case report: A 46 year-old woman was suffering from episodes of severe hypokalemia (K+ 1.9 - 3.4 mmol/l (ref. 3.5-5.1 mmol/l) and hypertensive crises up to 240/145 mm Hg for 4 years. She stated that there was no clear provoking factor for these epi...

Background: Primary hyperparathyroidism (PHPT) can present with not only classic complications like bone and kidney pathology but also with different metabolic disorders and cardiovascular diseases. The prevalence of diabetes mellitus type 2 (DM2) in patients with PHPT is higher than in general population but the mechanism of carbohydrate metabolism alteration in PHPT remains unclear.Aim: The aim of this study is to estimate parameters associated with im...